Overview
Non-clinical drug development is a structured, well thought out process. The aim is to determine which drug candidates have the probability of success and investigate their safety for later stages of development in collaboration with Research Institutions, Pharmaceuticals and Biotechnology companies.
ICP Firefly conducts safety testing in mammalian species ranging from single dose to lifespan. Specialist teams can perform a wide range of administration techniques.
Our specialist histopathologists and clinical pathologists will ensure identification of toxicity. The detailed reports include all the procedures and observations performed during a study. Tables and graphs are produced to facilitate the full understanding of the study. All our studies are performed in house.
Preclinical Toxicology Services
1. Non-GLP Toxicology Studies
Lead optimisation toxicology advances the lead candidate quickly by performing dose escalation and pilot studies; dose-ranging finding studies and toxicokinetic studies..
2. Development and Reproductive Toxicology
Development and reproductive studies require high levels of scientific expertise.
The species available are: Rodent (rat, mouse, rabbit)
The study designs are: fertility; developmental screening studies (OECD 421, 422); one to two generation studies (OECD 415, 416).
Administration routes include: dermal; gavage; implant; intracutaneous; intradermal; intranasal; intravenous; intraperitoneal; intrathecal; oral (gavage and diet); rectal; vaginal; subcutaneous and specific routes that you may require.
3. General Toxicology
At ICP Firefly, we offer a wide range of safety assessment services that range from lead optimization through to full GLP-compliant toxicology packages. Our comprehensive quotation system details all the costs involved and projected timelines.
The species available are: Rodent (rat, mouse, rabbit, guinea pig and dog)
The study durations are: single dose/special toxicity studies; dose-range-finding toxicity studies; sensitisation studies; sub chronic toxicity studies; chronic toxicity studies and carcinogenicity studies.
Administration routes include: dermal; gavage; implant; infusion; intracutaneous; intradermal; intranasal; intravenous; intraperitoneal; intrathecal; oral (gavage and diet); rectal; vaginal; subcutaneous.
4. Genetic and Molecular Toxicology
Genetic and molecular toxicology studies assess genetic damage and its consequences. ICP Firefly has more than 20 years of experience in the field. We offer in vitro and in vivo experiments to investigate the regulatory spectrum: Ames test; Gene mutation assay (Mouse lymphoma) and Micronucleus assay.
5. Research Models
We understand the importance of selecting the most appropriate research model for your next study
We have worked extensively with models ranging from tumour to cholesterol and bone density models.
6. Safety Pharmacology
Safety pharmacology investigations provide information about possible side-effects on the major physiological systems of the body. The services we provide include cardiovascular, respiratory and central nervous system investigations.
